Evolution of Mammalian Diving Capacity Traced by Myoglobin Net Surface Charge

@article{Mirceta2013EvolutionOM,
  title={Evolution of Mammalian Diving Capacity Traced by Myoglobin Net Surface Charge},
  author={Scott Mirceta and Anthony V. Signore and Jennifer M. Burns and Andrew R. Cossins and Kevin L. Campbell and Michael Berenbrink},
  journal={Science},
  year={2013},
  volume={340}
}
Introduction Evolution of extended breath-hold endurance enables the exploitation of the aquatic niche by numerous mammalian lineages and is accomplished by elevated body oxygen stores and morphological and physiological adaptations that promote their economical use. High muscle myoglobin concentrations in particular are mechanistically linked with an extended dive capacity phenotype, yet little is known regarding the molecular and biochemical underpinnings of this key specialization. We… 
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References

SHOWING 1-10 OF 272 REFERENCES
Functional properties of myoglobins from five whale species with different diving capacities
TLDR
Functional properties showed little species-specific differences in vitro, but a significant correlation was found between whale Mb concentration and average duration and depth of dives, and between O2 affinity and nitrite reductase activity when including horse Mb.
Ontogeny of oxygen stores and physiological diving capability in Australian sea lions
TLDR
Both dive depth and duration appear impacted by the slow development of oxygen stores in Australian sea lions, which has the slowest documented O2 store development among diving mammals.
Body size and skeletal muscle myoglobin of cetaceans: adaptations for maximizing dive duration.
  • S. Noren, T. Williams
  • Biology, Medicine
    Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
  • 2000
TLDR
Myoglobin content and body mass were both positively and significantly correlated to maximum dive duration in odontocetes; this differed from the relationship for mysticetes.
Myoglobin's old and new clothes: from molecular structure to function in living cells
TLDR
The analysis suggests that important differences can be observed whether steady-state or transient conditions are considered, and the role of myoglobin in oxygen transport in vertebrate heart and skeletal muscle, in the diving seal during apnea and the possible role of the analogous leghemoglobin of plants is addressed.
Functional differentiation of myoglobin isoforms in hypoxia-tolerant carp indicates tissue-specific protective roles.
  • S. Helbo, S. Dewilde, +4 authors A. Fago
  • Biology, Medicine
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2012
Because of a recent whole genome duplication, the hypoxia-tolerant common carp and goldfish are the only vertebrates known to possess two myoglobin (Mb) paralogs. One of these, Mb1, occurs in
Buffering capacity of vertebrate muscle: Correlations with potentials for anaerobic function
TLDR
The results indicate that muscle intracellular buffering capacity is especially critical in locomotory muscles which must function under conditions where circulatory perfusion is inadequate to rapidly remove the acidic end-products such as lactic acid that are produced by anaerobic glycolysis.
The ontogeny of aerobic and diving capacity in the skeletal muscles of Weddell seals
TLDR
To the authors' knowledge, this is the first quantitative account describing a decrease in aerobic fibers shifting towards an increase in fast-twitch oxidative fibers with a significant decrease in mitochondrial density as animals mature.
Diving Ability of the Platypus
TLDR
Estimates of available oxygen stores and oxygen consumption rate indicate little need for anaerobic metabolism during normal dives, and it is suggested that the platypus has the physiological capacity for greater underwater endurance than previously suggested.
Evolution of marine mammals: Back to the sea after 300 million years
  • M. Uhen
  • Biology, Medicine
    Anatomical record
  • 2007
TLDR
The earliest representatives of these clades all show morphological features that indicate they were feeding while in the water, suggesting that feeding ecology is a key factor in the evolution of marine mammals.
Evolution of vertebrate haemoglobins: Histidine side chains, specific buffer value and Bohr effect
  • M. Berenbrink
  • Biology, Medicine
    Respiratory Physiology & Neurobiology
  • 2006
TLDR
The analysis predicts that teleost fishes, passeriform birds and some snakes have independently evolved a much-reduced specific buffer value of Hb, possibly for enhancing the efficiency of an acid load to change oxygen affinity via the Bohr effect.
...
1
2
3
4
5
...