Evolution of MHC-G in humans and primates based on three new 3'UT polymorphisms.

  title={Evolution of MHC-G in humans and primates based on three new 3'UT polymorphisms.},
  author={Maria J. Castro and Pablo Franquelo Morales and J Martinez-Laso and Luis M Allende and R Rojo-Amigo and Mario Gonz{\'a}lez-Hevilla and Pilar Varela and Alberto Prieto Moreno and Miguel Garc{\'i}a-Berciano and Antonio Arnaiz-Villena},
  journal={Human immunology},
  volume={61 11},
MHC-G is a class Ib (non-classical) major histocompatibility complex (MHC) whose functional and evolutionary characteristics are still under scrutiny. The study of noncoding sequences in the MHC genes may provide important phylogenetic information. In this work we have sequenced the MHC-G exon 8, which encodes for the 3'UT region, in different species of primates. It has been shown that: (1) a previously described 14 base pair (bp) deletion polymorphism is human-specific and the HLA-G alleles… CONTINUE READING

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