Evolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease

@article{Li2018EvolutionOH,
  title={Evolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease},
  author={Zhen Li and David J. Polhemus and David J. Lefer},
  journal={Circulation Research},
  year={2018},
  volume={123},
  pages={590–600}
}
Hydrogen sulfide (H2S)—a potent gaseous signaling molecule—has emerged as a critical regulator of cardiovascular homeostasis. H2S is produced enzymatically by 3 constitutively active endogenous enzymes in all mammalian species. Within the past 2 decades, studies administering H2S-donating agents and the genetic manipulation of H2S-producing enzymes have revealed multiple beneficial effects of H2S, including vasodilation, activation of antiapoptotic and antioxidant pathways, and anti… Expand
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