Evolution of Hormone-Receptor Complexity by Molecular Exploitation

@article{Bridgham2006EvolutionOH,
  title={Evolution of Hormone-Receptor Complexity by Molecular Exploitation},
  author={Jamie T. Bridgham and Sean M. Carroll and Joseph W. Thornton},
  journal={Science},
  year={2006},
  volume={312},
  pages={101 - 97}
}
According to Darwinian theory, complexity evolves by a stepwise process of elaboration and optimization under natural selection. Biological systems composed of tightly integrated parts seem to challenge this view, because it is not obvious how any element's function can be selected for unless the partners with which it interacts are already present. Here we demonstrate how an integrated molecular system—the specific functional interaction between the steroid hormone aldosterone and its partner… 
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