Evolution of Hormone-Receptor Complexity by Molecular Exploitation

@article{Bridgham2006EvolutionOH,
  title={Evolution of Hormone-Receptor Complexity by Molecular Exploitation},
  author={J. Bridgham and S. Carroll and J. Thornton},
  journal={Science},
  year={2006},
  volume={312},
  pages={101 - 97}
}
  • J. Bridgham, S. Carroll, J. Thornton
  • Published 2006
  • Biology, Medicine
  • Science
  • According to Darwinian theory, complexity evolves by a stepwise process of elaboration and optimization under natural selection. Biological systems composed of tightly integrated parts seem to challenge this view, because it is not obvious how any element's function can be selected for unless the partners with which it interacts are already present. Here we demonstrate how an integrated molecular system—the specific functional interaction between the steroid hormone aldosterone and its partner… CONTINUE READING
    512 Citations

    Topics from this paper

    Evolution of steroid receptors from an estrogen-sensitive ancestral receptor
    • 116
    Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors
    • 92
    • PDF
    Mechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid Receptor
    • 55
    • PDF
    Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors
    • 55
    • PDF
    Neofunctionalization of Androgen Receptor by Gain-of-Function Mutations in Teleost Fish Lineage.
    • 21
    • PDF
    Evolution of hormone signaling in elasmobranchs by exploitation of promiscuous receptors.
    • 76
    • PDF
    Evolution of neuronal signalling: Transmitters and receptors
    • 26
    • Highly Influenced

    References

    SHOWING 1-10 OF 51 REFERENCES
    Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions
    • J. Thornton
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2001
    • 554
    • PDF
    The evolutionary origin of complex features
    • 629
    • PDF
    Principles for modulation of the nuclear receptor superfamily
    • 1,024
    Multiple aspects of mineralocorticoid selectivity.
    • 239
    • PDF
    Natural Selection and the Concept of a Protein Space
    • 562