Evolution of GPCR: Change and continuity

@article{Strotmann2011EvolutionOG,
  title={Evolution of GPCR: Change and continuity},
  author={Rainer Strotmann and Kristin Schr{\"o}ck and Iris B{\"o}selt and Claudia St{\"a}ubert and Andreas P. Russ and Torsten Sch{\"o}neberg},
  journal={Molecular and Cellular Endocrinology},
  year={2011},
  volume={331},
  pages={170-178}
}

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References

SHOWING 1-10 OF 145 REFERENCES
G protein-coupled time travel: evolutionary aspects of GPCR research.
TLDR
Recent advances and approaches aimed at developing a better understanding of GPCR biology based on evolutionary data are discussed.
The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes
TLDR
The results show that the main families in the human genome, Glutamate, Rhodopsin, Adhesion, Frizzled, and Secretin, arose before the split of nematodes from the chordate lineage.
The Dictyostelium repertoire of seven transmembrane domain receptors.
Evolution of secretin family GPCR members in the metazoa
TLDR
The family 2 GPCR members provide a good example of gene duplication events occurring in tandem with increasing organismal complexity during metazoan evolution.
The Structural Evolution of a P2Y-like G-protein-coupled Receptor*
TLDR
Evolution is mined as an additional source of structural information that may guide GPCR model generation as well as mutagenesis studies and indicates that maintaining the unique function of rhodopsin requires a more stringent network of relevant intramolecular constrains.
The Adhesion GPCRs: A unique family of G protein-coupled receptors with important roles in both central and peripheral tissues
TLDR
Phylogenetic analysis of the entire repertoire of the seven transmembrane- domain (7TM) regions of GPCR shows that the Adhesion GPCRs form a distinct family, and it is speculated that the overall structural construction of theAdhesion G PCRs allows them to participate in different types of cell guidance.
Expansion of the Superfamily of G‐Protein‐Coupled Receptors in Chordates
TLDR
The 5 main families found in mammals are present before the divergence of nematodes, and several classes of GPCRs are not present within the vertebrate lineage, whereas they are present in several other taxa.
...
...