Evolution of CD8+ T cell immunity and viral escape following acute HIV-1 infection.

@article{Cao2003EvolutionOC,
  title={Evolution of CD8+ T cell immunity and viral escape following acute HIV-1 infection.},
  author={Jianhong Cao and John McNevin and Uma Malhotra and M Juliana McElrath},
  journal={Journal of immunology},
  year={2003},
  volume={171 7},
  pages={3837-46}
}
Induction of HIV-1-specific CD8(+) T cells during acute infection is associated with a decline in viremia. The role CD8(+) effectors play in subsequently establishing viral set point remains unclear. To address this, we focused on two acutely infected patients with the same initial Tat-specific CD8(+) response, analyzing their CD8(+) T cell responses longitudinally in conjunction with viral load and sequence evolution. In one patient initiating treatment during acute infection, the frequencies… CONTINUE READING

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