Evolution of C-H Bond Functionalization from Methane to Methodology.

  title={Evolution of C-H Bond Functionalization from Methane to Methodology.},
  author={John F Hartwig},
  journal={Journal of the American Chemical Society},
  volume={138 1},
This Perspective presents the fundamental principles, the elementary reactions, the initial catalytic systems, and the contemporary catalysts that have converted C-H bond functionalization from a curiosity to a reality for synthetic chemists. Many classes of elementary reactions involving transition-metal complexes cleave C-H bonds at typically unreactive positions. These reactions, coupled with a separate or simultaneous functionalization process lead to products containing new C-C, C-N, and C… CONTINUE READING
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