Evolution of Bcl-2 homology motifs: homology versus homoplasy.

  title={Evolution of Bcl-2 homology motifs: homology versus homoplasy.},
  author={Abdel Aouacheria and Valentine Rech de Laval and Christophe Combet and Jonathan Hardwick},
  journal={Trends in cell biology},
  volume={23 3},
Bcl-2 family proteins regulate apoptosis in animals. This protein family includes several homologous proteins and a collection of other proteins lacking sequence similarity except for a Bcl-2 homology (BH)3 motif. Thus, membership in the Bcl-2 family requires only one of the four BH motifs. On this basis, a growing number of diverse BH3-only proteins are being reported. Although compelling cell biological and biophysical evidence validates many BH3-only proteins, claims of significant BH3… CONTINUE READING
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