Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene.

@article{Gauwerky1988EvolutionOB,
  title={Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene.},
  author={C E Gauwerky and Frank G. Haluska and Yoshihide Tsujimoto and Peter C. Nowell and Carlo M. Croce},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 22},
  pages={8548-52}
}
We have analyzed the molecular genetics of the breakpoints involved in the t(8;14) and t(14;18) translocations of an acute pre-B-cell leukemia from a patient with a history of follicular lymphoma. In this patient's leukemic cells, the breakpoint of the t(14;18) translocation occurred in the major breakpoint-cluster region of the BCL2 gene and became linked to the JH4 joining-region gene segment of the immunoglobulin heavy-chain locus on the 14q+ chromosome as previously observed in follicular… CONTINUE READING

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