Evolution of Atg1 function and regulation.

  title={Evolution of Atg1 function and regulation.},
  author={Edmond Y. W. Chan and Sharon A Tooze},
  volume={5 6},
The serine/threonine kinase Atg1 plays an essential role downstream of TOR for the regulation of autophagy. In yeast, where Atg1 was first identified, a complex regulatory mechanism has been described that includes at least seven other interacting proteins and a phosphorylation-dependent switch. Recent findings confirm that the mammalian Atg1 homologues ULK1 and 2 have autophagy regulatory roles. However, we and others have also demonstrated mechanistic differences with the yeast model and… CONTINUE READING