Evolution of ATP-binding cassette transporter genes.

  title={Evolution of ATP-binding cassette transporter genes.},
  author={Michael Dean and Rando L. Allikmets},
  journal={Current opinion in genetics & development},
  volume={5 6},
The transport of molecules across lipid membranes is an essential function of all living organisms. One of the families of genes that have evolved to carry out this function is that which encodes the ATP-binding cassette proteins. These molecules use active transport to pump specific molecules across membranes, and the genes that encode them are found in abundance in the genomes of both prokaryotes and eukaryotes. By using gene disruption techniques and by studying homologous genes in model… CONTINUE READING