Evolution in the Conceptualization of Dementia and Alzheimer’s Disease: Greco-Roman Period to the 1960s

  title={Evolution in the Conceptualization of Dementia and Alzheimer’s Disease: Greco-Roman Period to the 1960s},
  author={Nicole C. Berchtold and Carl Cotman},
  journal={Neurobiology of Aging},
History of Dementia.
  • F. Assal
  • Psychology, Medicine
    Frontiers of neurology and neuroscience
  • 2019
The term dementia derives from the Latin root demens, which means being out of one's mind, and has been used since the 13th century, but its mention in the medical community was reported in the 18th century.
Alzheimer's 100th anniversary of death and his contribution to a better understanding of Senile dementia.
Alois Alzheimer's examination of Auguste D's case, studied by him with Bielschowsky's silver impregnation technique, permitted to identify a pathological marker, the intraneuronal neurofibrillary tangles, characterizing a new disease later named after him - Alzheimer's disease.
Alzheimer 100 – highlights in the history of Alzheimer research
Summary.Alzheimer disease, a progressive neurodegenerative disorder of hitherto unknown etiology leading progressively to severe incapacity and death, has become the pandemic of the 21st century. On
Changing perspectives regarding late-life dementia
These concepts, formulated as the dynamic polygon hypothesis, have major implications for clinical trials, as any given drug might not be ideal for all elderly people with dementia.
Editorial Longitudinal Epidemiologic Clinical-Pathologic Studies of Aging and Alzheimer's Disease
A complete picture of AD would require the clinical study of people with a wide range of cognitive functioning, especially persons without dementia, who subsequently come under the scrutiny of clinical-pathologic studies.
Historical review of academic concepts of dementia in the world and Japan: with a short history of representative diseases
The trajectory of the concepts of dementia in the world and Japan are reviewed and the present concept of dementia was established in 1970s.
Since Alzheimer's disease is not cured completely and it gradually renders people incapable of tending for their own needs, caregiving essentially is the treatment and must be carefully managed over the course of the disease.
Molecular Pathology of Alzheimer's Disease
This book details the discovery of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the cases of the neurofibrillary tangle in Alzheimer’s Disease.
Dementia in the Greco-Roman world


Origin of the distinction between Alzheimer's disease and senile dementia
History reveals that the distinction between presenile (Alzheimer's disease) and senile dementia was originally based on anecdotal clinical observations and that competition among universities was one of the underlying determinants.
Dementia: Historical Overview
To prevent projecting onto the past perspectives that belong to the present, historical method recommends that a historical overview of dementia distinguish between the history of the word and that
Clinical subgroups of the Alzheimer syndrome
Because the heterogeneity of AD is incontestable, it is time to reconsider the current use of the term “Alzheimer's disease,” and the term” Alzheimer syndrome” appears to be more appropriate.
Familial Alzheimer's disease
This investigation has dealt with the study of a family in which 11 members in recent generations and 2 additional members in 2 past generations have been found to have signs and symptoms of a syndrome consisting of progressive mental deterioration, aphasia, seizures, myoclonus, immobile facies, plastic rigidity, and semiflexed posture.
Dementia during the seventeenth and eighteenth centuries: a conceptual history
  • G. Berríos
  • History, Psychology
    Psychological Medicine
  • 1987
It is shown that the concept of dementia took final shape in the work of Willis, Hartley and Cullen in whose view it was made to include terminal states of behavioural incompetence due to severe failure of almost any mental function.
Correlation between Scores for Dementia and Counts of ‘Senile Plaques’ in Cerebral Grey Matter of Elderly Subjects
An attempt was made to carry out a quantitative assessment of the severity of dementia in individual subjects during life and to ascertain whether this bore any relationship with mean plaque counts in cerebral grey matter.
Of 10 cases, occurring at an age prior to the presenile stage, seven presented either insufficient pathological and clinical elements or typical pathology but non-characteristic clinical symptoms, and their inclusion in the group of Alzheimer's disease cannot be made without unduly stretching the original conception of the malady.
Dementia: A survey of the syndrome of dementia
  • B. Mahendra
  • Medicine, Psychology
    Psychological Medicine
  • 1985
Three points must strike anyone who has embarked on a study of dementia over a period of time that the conception of the syndrome is in a state of flux and what the criteria for, and also who the arbiters of, the diagnosis might be is not always clear.
The natural history of mental disorder in old age.
  • M. Roth
  • Medicine, Psychology
    The Journal of mental science
  • 1955
Examination of differences in pattern of outcome between specific groups provides strong confirmation for hypotheses suggesting that affective psychosis, late paraphrenia and acute confusion were each entities largely independent of the two main causes of progressive dementia in old age: senile and arteriosclerotic psychosis.