Evolution in the Conceptualization of Dementia and Alzheimer’s Disease: Greco-Roman Period to the 1960s

@article{Berchtold1998EvolutionIT,
  title={Evolution in the Conceptualization of Dementia and Alzheimer’s Disease: Greco-Roman Period to the 1960s},
  author={Nicole C. Berchtold and Carl Cotman},
  journal={Neurobiology of Aging},
  year={1998},
  volume={19},
  pages={173-189}
}
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370 Citations
Highly Influential Citations
23
Background Citations
169
Methods Citations
6
Results Citations
2

370 Citations

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Alois Alzheimer's examination of Auguste D's case, studied by him with Bielschowsky's silver impregnation technique, permitted to identify a pathological marker, the intraneuronal neurofibrillary tangles, characterizing a new disease later named after him - Alzheimer's disease.
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Summary.Alzheimer disease, a progressive neurodegenerative disorder of hitherto unknown etiology leading progressively to severe incapacity and death, has become the pandemic of the 21st century. On…
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These concepts, formulated as the dynamic polygon hypothesis, have major implications for clinical trials, as any given drug might not be ideal for all elderly people with dementia.
Editorial Longitudinal Epidemiologic Clinical-Pathologic Studies of Aging and Alzheimer's Disease
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A complete picture of AD would require the clinical study of people with a wide range of cognitive functioning, especially persons without dementia, who subsequently come under the scrutiny of clinical-pathologic studies.
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The trajectory of the concepts of dementia in the world and Japan are reviewed and the present concept of dementia was established in 1970s.
ALZHEIMER'S DISEASE - PATHOPHYSIOLOGY, DIAGNOSIS AND MODERN APPROACH OF TREATMENT
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Since Alzheimer's disease is not cured completely and it gradually renders people incapable of tending for their own needs, caregiving essentially is the treatment and must be carefully managed over the course of the disease.
Molecular Pathology of Alzheimer's Disease
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This book details the discovery of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the cases of the neurofibrillary tangle in Alzheimer’s Disease.
Dementia in the Greco-Roman world
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