Evolution in silico and in vitro: the RNA model.

@article{Schuster2001EvolutionIS,
  title={Evolution in silico and in vitro: the RNA model.},
  author={Peter Schuster},
  journal={Biological chemistry},
  year={2001},
  volume={382 9},
  pages={1301-14}
}
Theoretical concepts and experiments dealing with the evolution of molecules in vitro reached a state that allows for direct applications to the design of biomolecules with predefined properties. RNA evolution in vitro represents a basis for the development of a new and comprehensive model of evolution, focusing on the phenotype and its fitness relevant properties. Relations between genotypes and phenotypes are described by mappings from genotype space onto a space of phenotypes, which are many… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Diverse mutants of HIV RRE IIB recognize wild-type Rev ARM or Rev ARM R35G-N40V.

Journal of molecular recognition : JMR • 2015
View 13 Excerpts
Highly Influenced

From Molecular Systems to Simple Cells : a Study of the Genotype-Phenotype Map

Mag Camille, Stephan-Otto Attolini, +6 authors Iv Zusammenfassung
2005
View 3 Excerpts
Highly Influenced

Folding and finding RNA secondary structure.

Cold Spring Harbor perspectives in biology • 2010
View 1 Excerpt

A minimal and self-consistent in silico cell model based on macromolecular interactions.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 2007
View 2 Excerpts

Determinants of simulated RNA evolution.

Journal of theoretical biology • 2006
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Genomic evolution during a 10,000-generation experiment with bacteria.

Proceedings of the National Academy of Sciences of the United States of America • 1999
View 5 Excerpts
Highly Influenced

Smoothness within ruggedness: the role of neutrality in adaptation.

Proceedings of the National Academy of Sciences of the United States of America • 1996
View 5 Excerpts
Highly Influenced

A constant rate of spontaneous mutation in DNA-based microbes.

Proceedings of the National Academy of Sciences of the United States of America • 1991
View 2 Excerpts
Highly Influenced

Physical aspects of evolutionary optimization and adaptation.

Physical review. A, General physics • 1989
View 4 Excerpts
Highly Influenced

Molecular insight into the evolution of phenotypes

P. Schuster
In: Crutchfield, J.P., and Schuster, P. Evolutionary dynamics - Exploring the interplay of accident, selection, neutrality, and function. Oxford University Press, New York, in press. • 2001
View 2 Excerpts

Similar Papers

Loading similar papers…