Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents.

@article{Chen2015EvolutionIM,
  title={Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents.},
  author={Haijun Chen and Yu Gao and Ailan Wang and Xiaobin Zhou and Yunquan Zheng and Jia Zhou},
  journal={European journal of medicinal chemistry},
  year={2015},
  volume={92},
  pages={
          648-55
        }
}
Currently, there is a renewed interest in common dietaries and plant-based traditional medicines for the prevention and treatment of cancer. In the search for potential anticancer agents from natural sources, ursolic acid (UA), a pentacyclic triterpenoid widely found in various medicinal herbs and fruits, exhibits powerful biological effects including its attractive anticancer activity against various types of cancer cells. However, the limited solubility, rapid metabolism and poor… Expand
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