Evolution in health and medicine Sackler colloquium: Consanguinity, human evolution, and complex diseases.

@article{Bittles2010EvolutionIH,
  title={Evolution in health and medicine Sackler colloquium: Consanguinity, human evolution, and complex diseases.},
  author={Alan H. Bittles and Michael L. Black},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 Suppl 1},
  pages={1779-86}
}
There is little information on inbreeding during the critical early years of human existence. However, given the small founding group sizes and restricted mate choices it seems inevitable that intrafamilial reproduction occurred and the resultant levels of inbreeding would have been substantial. Currently, couples related as second cousins or closer (F >or= 0.0156) and their progeny account for an estimated 10.4% of the global population. The highest rates of consanguineous marriage occur in… CONTINUE READING

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