Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians.

@article{Atzmon2010EvolutionIH,
  title={Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians.},
  author={Gil Atzmon and Miook Cho and Richard M. Cawthon and Temuri Budagov and Micol Katz and Xiaoman Yang and Glenn Siegel and Aviv Bergman and Derek M. Huffman and Clyde B. Schechter and Woodring E Wright and Jerry W Shay and Nir Barzilai and Diddahally R. Govindaraju and Yousin Suh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 Suppl 1},
  pages={1710-7}
}
Telomere length in humans is emerging as a biomarker of aging because its shortening is associated with aging-related diseases and early mortality. However, genetic mechanisms responsible for these associations are not known. Here, in a cohort of Ashkenazi Jewish centenarians, their offspring, and offspring-matched controls, we studied the inheritance and maintenance of telomere length and variations in two major genes associated with telomerase enzyme activity, hTERT and hTERC. We demonstrated… CONTINUE READING
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