Evolution by the birth-and-death process in multigene families of the vertebrate immune system.

@article{Nei1997EvolutionBT,
  title={Evolution by the birth-and-death process in multigene families of the vertebrate immune system.},
  author={Masatoshi Nei and Xun Gu and Tatiana Sitnikova},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 15},
  pages={
          7799-806
        }
}
Concerted evolution is often invoked to explain the diversity and evolution of the multigene families of major histocompatibility complex (MHC) genes and immunoglobulin (Ig) genes. However, this hypothesis has been controversial because the member genes of these families from the same species are not necessarily more closely related to one another than to the genes from different species. To resolve this controversy, we conducted phylogenetic analyses of several multigene families of the MHC… CONTINUE READING
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