Evolution by small steps and rugged landscapes in the RNA virus phi6.

@article{Burch1999EvolutionBS,
  title={Evolution by small steps and rugged landscapes in the RNA virus phi6.},
  author={Christina L Burch and Lin Rui Chao},
  journal={Genetics},
  year={1999},
  volume={151 3},
  pages={921-7}
}
Fisher's geometric model of adaptive evolution argues that adaptive evolution should generally result from the substitution of many mutations of small effect because advantageous mutations of small effect should be more common than those of large effect. However, evidence for both evolution by small steps and for Fisher's model has been mixed. Here we report supporting results from a new experimental test of the model. We subjected the bacteriophage phi6 to intensified genetic drift in small… CONTINUE READING

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