Evolution and transmission of stable CTL escape mutations in HIV infection

@article{Goulder2001EvolutionAT,
  title={Evolution and transmission of stable CTL escape mutations in HIV infection},
  author={P. Goulder and C. Brander and Yanhua Tang and C. Tremblay and R. Colbert and M. Addo and E. Rosenberg and Thi H O Nguyen and R. Allen and A. Trocha and M. Altfeld and Suqin He and M. Bunce and R. Funkhouser and S. Pelton and S. Burchett and K. Mcintosh and B. Korber and B. Walker},
  journal={Nature},
  year={2001},
  volume={412},
  pages={334-338}
}
Increasing evidence indicates that potent anti-HIV-1 activity is mediated by cytotoxic T lymphocytes (CTLs); however, the effects of this immune pressure on viral transmission and evolution have not been determined. Here we investigate mother–child transmission in the setting of human leukocyte antigen (HLA)-B27 expression, selected for analysis because it is associated with prolonged immune containment in adult infection. In adults, mutations in a dominant and highly conserved B27-restricted… Expand
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