Evolution and tinkering.

  title={Evolution and tinkering.},
  author={F. Jacob},
  volume={196 4295},
  • F. Jacob
  • Published 1977
  • Biology, Medicine
  • Science
A Simple Combinatorial Model of World Economic History
We use a simple combinatorial model of technological change to explain the Industrial Revolution. The Industrial Revolution was a sudden large improvement in technology, which resulted in significantExpand
Metaphor and Meaning in the Teleological Language of Biology
It is concluded that, since teleological concepts cannot be abstracted away from biological explanations without loss of meaning and explanatory power, life is inherently teleological. Expand
BMP controls dorsoventral and neural patterning in indirect-developing hemichordates providing insight into a possible origin of chordates
It is found that in the hemichordate larva, BMP signaling is required for DV patterning and is sufficient to repress neurogenesis, and this findings provide a mechanistic basis to support the hypothesis that an inverse chordate body plan emerged from an indirect-developing ancestor by tinkering with B MP signaling. Expand
Evolutionary Genomics
Part I: Phylogenomics 1. Tangled Trees: The Challenge of Inferring Species Trees from Coalescent and Non-Coalescent Genes Christian Anderson, Liang Liu, Dennis Pearl, and Scott V. Edwards 2. ModelingExpand
Natural reward as the fundamental macroevolutionary force
This work identifies a separate struggle and an alternative evolutionary force that drives the advancement of life by a process of extinction-replacement megaevolution that releases constraints on progress and increases the innovativeness of life. Expand
The Design of UDOO Boards: Contributing to the Appropriation of Digital Technology
The concept of appropriation is reviewed and bricolage is presented as a key activity for fostering appropriation and the Makers Movement as a socio-cultural movement relevant for the process of appropriation of digital technology is presented. Expand
Verifying Feighner’s Hypothesis; Anorexia Nervosa Is Not a Psychiatric Disorder
The results indicate that psychiatric diagnoses, which are reliable and valid in patients with psychiatric disorders, are less well suited for patients with anorexia, and support the alternative, clinically relevant hypothesis that the behavioral phenotype of the patients should be addressed directly. Expand
Genetic and developmental origins of a unique foraging adaptation in a Lake Malawi cichlid genus
Genetic and genomic mapping show that core members of canonical Tgfβ signaling segregate with quantitative trait loci for snout variation, and experimental up-regulation of Tfβ is sufficient to produce an expansion of scx expression and concomitant changes in snout morphology. Expand
The Origin of Life: Models and Data
OOL models based on privileged functions necessarily depend on “takeovers” to transition from previous genetic and catalytic systems to the extant DNA/RNA/protein system, requiring replacement of one Molecular Toolbox with another and of one Universal Gene Set with another. Expand
An ancient dental gene set governs development and continuous regeneration of teeth in sharks.
It is suggested that at the dawn of the vertebrate lineage, teeth were most likely continuously regenerative structures, and a core set of genes from members of key developmental signalling pathways were instrumental in creating a dental legacy redeployed throughout vertebrate evolution. Expand


/links.jstor.org/sici?sici=0014-3820%28195209%296%3A3%3C342%3AHMS%3E2.0.CO%3B2-E 11 Evolution at Two Levels in Humans and Chimpanzees Mary-Claire King
  • C. Wilson Science, New Series
  • 1975
Evolution at two levels in humans and chimpanzees.
Psychosomatic Disease and the "Visceral Brain": Recent Developments Bearing on the Papez Theory of Emotion
  • P. Maclean
  • Psychology, Medicine
  • Psychosomatic medicine
  • 1949
Little information has accumulated to indicate by what mechanism the emotions can so act on autonomic centers as to lead to diseases as diverse as essential hypertension, peptic ulcer, asthma, etc. Expand
NOTE: The reference numbering from the original has been maintained in this citation list
  • NOTE: The reference numbering from the original has been maintained in this citation list
and Notes 4 How Many Species?
  • and Notes 4 How Many Species?