Evolution and tinkering.

  title={Evolution and tinkering.},
  author={François Jacob},
  volume={196 4295},
  • F. Jacob
  • Published 10 June 1977
  • Education
  • Science
Stepping From Modeling Cancer Plasticity to the Philosophy of Cancer
This article postulates the existence in all Metazoans of a coding system analogous to the MHC of jawed vertebrates that is present in all its forerunners in animal evolution, and poses that the immune system is the coordinator of the unity of the organism.
A Simple Combinatorial Model of World Economic History
We use a simple combinatorial model of technological change to explain the Industrial Revolution. The Industrial Revolution was a sudden large improvement in technology, which resulted in significant
DHQ: Digital Humanities Quarterly: Researcher as Bricoleur: Contextualizing humanists’ digital workflows
It is concluded that in humanists’ workflows digital and analog tools and resources do not necessarily replace one another or vie for the dominant position, and supplement each other in an interconnected, hybrid workflow that comes to respondents as an organic manifestation of their work.
Metaphor and Meaning in the Teleological Language of Biology
It is concluded that, since teleological concepts cannot be abstracted away from biological explanations without loss of meaning and explanatory power, life is inherently teleological.
Verifying Feighner’s Hypothesis; Anorexia Nervosa Is Not a Psychiatric Disorder
The results indicate that psychiatric diagnoses, which are reliable and valid in patients with psychiatric disorders, are less well suited for patients with anorexia, and support the alternative, clinically relevant hypothesis that the behavioral phenotype of the patients should be addressed directly.
BMP controls dorsoventral and neural patterning in indirect-developing hemichordates providing insight into a possible origin of chordates
It is found that in the hemichordate larva, BMP signaling is required for DV patterning and is sufficient to repress neurogenesis, and this findings provide a mechanistic basis to support the hypothesis that an inverse chordate body plan emerged from an indirect-developing ancestor by tinkering with B MP signaling.
Natural reward as the fundamental macroevolutionary force
This work identifies a separate struggle and an alternative evolutionary force that drives the advancement of life by a process of extinction-replacement megaevolution that releases constraints on progress and increases the innovativeness of life.
Evolutionary Genomics
Part I: Phylogenomics 1. Tangled Trees: The Challenge of Inferring Species Trees from Coalescent and Non-Coalescent Genes Christian Anderson, Liang Liu, Dennis Pearl, and Scott V. Edwards 2. Modeling
The Design of UDOO Boards: Contributing to the Appropriation of Digital Technology
The concept of appropriation is reviewed and bricolage is presented as a key activity for fostering appropriation and the Makers Movement as a socio-cultural movement relevant for the process of appropriation of digital technology is presented.
Genetic and developmental origins of a unique foraging adaptation in a Lake Malawi cichlid genus
Genetic and genomic mapping show that core members of canonical Tgfβ signaling segregate with quantitative trait loci for snout variation, and experimental up-regulation of Tfβ is sufficient to produce an expansion of scx expression and concomitant changes in snout morphology.


Psychosomatic Disease and the "Visceral Brain": Recent Developments Bearing on the Papez Theory of Emotion
Little information has accumulated to indicate by what mechanism the emotions can so act on autonomic centers as to lead to diseases as diverse as essential hypertension, peptic ulcer, asthma, etc.
Evolution by Gene Duplication
The Meaning of Evolution (Yale
  • 1967
This content downloaded from on Wed
    Evolution by Gene Duplication (Springer-Verlag
    • New York,
    • 1970
    and Notes 4 How Many Species?
    • and Notes 4 How Many Species?
    NOTE: The reference numbering from the original has been maintained in this citation list
    • NOTE: The reference numbering from the original has been maintained in this citation list
    /links.jstor.org/sici?sici=0014-3820%28195209%296%3A3%3C342%3AHMS%3E2.0.CO%3B2-E 11 Evolution at Two Levels in Humans and Chimpanzees Mary-Claire King
    • C. Wilson Science, New Series
    • 1975
    Hemoglobins in Genetics and Evolution (Columbia
    • 1963