Evolution and pathophysiology of the human natural anti-α-galactosyl IgG (anti-Gal) antibody

@article{Galili2004EvolutionAP,
  title={Evolution and pathophysiology of the human natural anti-$\alpha$-galactosyl IgG (anti-Gal) antibody},
  author={Uri Galili},
  journal={Springer Seminars in Immunopathology},
  year={2004},
  volume={15},
  pages={155-171}
}
  • U. Galili
  • Published 2004
  • Biology
  • Springer Seminars in Immunopathology
SummaryAnti-Gal is a human natural antibody which interacts specifically with the mammalian carbohydrate structure Galα1-3Galβ1-4GlcNAc-R, termed, the α-galactosyl epitope. This antibody constitutes approximately 1% of circulating IgG in human serum and is produced, upon stimulation, by 1% of circulating B lymphocytes. Anti-Gal is also present as IgA antibodies in body secretions such as saliva, milk and colostrum. The antigenic source for the constant production of anti-Gal seems to be the… 

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