Evolution and overview of classical transmitter molecules and their receptors.

@article{Walker1996EvolutionAO,
  title={Evolution and overview of classical transmitter molecules and their receptors.},
  author={Robert J. Walker and Heddwen L. Brooks and Lindy Holden-Dye},
  journal={Parasitology},
  year={1996},
  volume={113 Suppl},
  pages={S3-33}
}
All the classical transmitter ligand molecules evolved at least 1000 million years ago. With the possible exception of the Porifera and coelenterates (Cnidaria), they occur in all the remaining phyla. All transmitters have evolved the ability to activate a range of ion channels, resulting in excitation, inhibition and biphasic or multiphasic responses. All transmitters can be synthesised in all three basic types of neurones, i.e. sensory, interneurone and motoneurone. However their relative… CONTINUE READING