Evolution and obesity: resistance of obese-prone rats to a challenge of food restriction and wheel running

@article{Pierce2010EvolutionAO,
  title={Evolution and obesity: resistance of obese-prone rats to a challenge of food restriction and wheel running},
  author={William D Pierce and Abdoulaye Dian{\'e} and C. Donald Heth and James C. Russell and Spencer D. Proctor},
  journal={International Journal of Obesity},
  year={2010},
  volume={34},
  pages={589-592}
}
The adaptive hypothesis that an obese-prone genotype confers a fitness advantage when challenged with food restriction and food-related locomotion was tested using a rat model. Juvenile (35–40 days) and adolescent (45–50 days) JCR:LA-cp rats, obese prone (cp/cp) and lean prone (+/?), were exposed to 1.5 h daily meals and 22.5 h of voluntary wheel running, a procedure that normally leads to self-starvation. Genotype had a dramatic effect on survival of rats when exposed to the challenge of food… CONTINUE READING
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among men and women

  • SY Pan, M. DesMeules
  • Obesity
  • 2009

epidemic: natural selection of thrifty genes or genetic drift following predation release

  • A Routtenberg, A. Kuznesof
  • Int J Obesity
  • 2008

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