Evolution and human tissue expression of the Cres/Testatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cystatins.

@article{Frygelius2010EvolutionAH,
  title={Evolution and human tissue expression of the Cres/Testatin subgroup genes, a reproductive tissue specific subgroup of the type 2 cystatins.},
  author={Jessica Frygelius and Lars Arvestad and Anna Wedell and Virpi T{\"o}h{\"o}nen},
  journal={Evolution & development},
  year={2010},
  volume={12 3},
  pages={329-42}
}
The cystatin family comprises a group of generally broadly expressed protease inhibitors. The Cres/Testatin subgroup (CTES) genes within the type 2 cystatins differs from the classical type 2 cystatins in having a strikingly reproductive tissue-specific expression, and putative functions in reproduction have therefore been discussed. We have performed evolutionary studies of the CTES genes based on gene searches in genomes from 11 species. Ancestors of the cystatin family can be traced back to… CONTINUE READING

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