Evolution and genetic characterization of hepatitis A virus isolates in China.

@article{Wang2015EvolutionAG,
  title={Evolution and genetic characterization of hepatitis A virus isolates in China.},
  author={Hao Chun Wang and Xinying Wang and Hui-hui Zheng and Jing-yuan Cao and Wen-ting Zhou and Sheng-li Bi},
  journal={International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases},
  year={2015},
  volume={33},
  pages={156-8}
}
OBJECTIVES Hepatitis A virus (HAV), transmitted mainly through the fecal-oral route, is one of the major causes of acute viral hepatitis worldwide. HAV is endemic in China. This study performed genetic and evolutionary analysis of HAV isolates circulated in the country. METHODS Clinical samples were collected and HAV nucleotide and deduced amino acid sequences were analyzed. 70 representative sequences of HAV VP3-VP1-2A regions sampled from 1988 to 2014 were compared and characterized using… CONTINUE READING

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