Evolution and functions of Oct4 homologs in non-mammalian vertebrates.

@article{Onichtchouk2016EvolutionAF,
  title={Evolution and functions of Oct4 homologs in non-mammalian vertebrates.},
  author={Daria Onichtchouk},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1859 6},
  pages={
          770-9
        }
}
PouV class transcription factor Oct4/Pou5f1 is a central regulator of indefinite pluripotency in mammalian embryonic stem cells (ESCs) but also participates in cell lineage specification in mouse embryos and in differentiating cell cultures. The molecular basis for this versatility, which is shared between Oct4 and its non-mammalian homologs Pou5f1 and Pou5f3, is not yet completely understood. Here, I review the current understanding of the evolution of PouV class transcription factors and… CONTINUE READING
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