Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology.

@article{Malavasi2008EvolutionAF,
  title={Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology.},
  author={Fabio Malavasi and Silvia Deaglio and Ada Funaro and Enza Ferrero and A L Horenstein and {\'E}rika Veruska Paiva Ortolan and Tiziana Vaisitti and Semra Aydin},
  journal={Physiological reviews},
  year={2008},
  volume={88 3},
  pages={841-86}
}
The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most tissues, CD38 (and CD157) cleaves NAD(+) and NADP(+), generating cyclic ADP ribose (cADPR), NAADP, and ADPR. These reaction products are essential for the regulation of intracellular Ca(2+), the most ancient and universal cell signaling system. The entire family of enzymes controls complex processes, including egg… CONTINUE READING
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