Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase

@article{Rogozin2007EvolutionAD,
  title={Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase},
  author={Igor B. Rogozin and Lakshminarayan M. Iyer and Lizhi Liang and Galina V. Glazko and Victoria G Liston and Youri I. Pavlov and L. Aravind and Zeev Pancer},
  journal={Nature Immunology},
  year={2007},
  volume={8},
  pages={647-656}
}
The variable lymphocyte receptors (VLRs) of jawless vertebrates such as lamprey and hagfish are composed of highly diverse modular leucine-rich repeats. Each lymphocyte assembles a unique VLR by rearrangement of the germline gene. In the lamprey genome, we identify here about 850 distinct cassettes encoding leucine-rich repeat modules that serve as sequence templates for the hypervariable VLR repertoires. The data indicate a gene conversion–like process in VLR diversification. Genomic analysis… CONTINUE READING