Evolution and divergence of the mammalian SAMD9/SAMD9L gene family

  title={Evolution and divergence of the mammalian SAMD9/SAMD9L gene family},
  author={Ana Lemos de Matos and Jia Liu and Grant Mcfadden and Pedro J Esteves},
  booktitle={BMC Evolutionary Biology},
The physiological functions of the human Sterile Alpha Motif Domain-containing 9 (SAMD9) gene and its chromosomally adjacent paralogue, SAMD9-like (SAMD9L), currently remain unknown. However, the direct links between the deleterious mutations or deletions in these two genes and several human disorders, such as inherited inflammatory calcified tumors and acute myeloid leukemia, suggest their biological importance. SAMD9 and SAMD9L have also recently been shown to play key roles in the innate… CONTINUE READING
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