Evolution and dissemination of beta-lactamases accelerated by generations of beta-lactam antibiotics.

@article{Medeiros1997EvolutionAD,
  title={Evolution and dissemination of beta-lactamases accelerated by generations of beta-lactam antibiotics.},
  author={Antone A. Medeiros},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={1997},
  volume={24 Suppl 1},
  pages={S19-45}
}
beta-Lactamases are the principal mechanism of bacterial resistance to beta-lactam antibiotics. In recent years the number and variety of new beta-lactamases detected has risen at an alarming rate, apparently in response to the clinical use of novel classes of beta-lactam antibiotics. This paper reviews the structure and evolution of beta-lactamases in an attempt to understand the pressures that have contributed to their emergence. 
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