Evolution and Phenotypic Selection of Cancer Stem Cells

  title={Evolution and Phenotypic Selection of Cancer Stem Cells},
  author={Jan Poleszczuk and Philip Hahnfeldt and Heiko Enderling},
  booktitle={PLoS Computational Biology},
Cells of different organs at different ages have an intrinsic set of kinetics that dictates their behavior. Transformation into cancer cells will inherit these kinetics that determine initial cell and tumor population progression dynamics. Subject to genetic mutation and epigenetic alterations, cancer cell kinetics can change, and favorable alterations that increase cellular fitness will manifest themselves and accelerate tumor progression. We set out to investigate the emerging intratumoral… CONTINUE READING