Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response

@inproceedings{Shokal2017EvolutionAF,
  title={Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response},
  author={Upasana Shokal and Ioannis Eleftherianos},
  booktitle={Front. Immunol.},
  year={2017}
}
The innate immune response is evolutionary conserved among organisms. The complement system forms an important and efficient immune defense mechanism. It consists of plasma proteins that participate in microbial detection, which ultimately results in the production of various molecules with antimicrobial activity. Thioester-containing proteins (TEPs) are a superfamily of secreted effector proteins. In vertebrates, certain TEPs act in the innate immune response by promoting recruitment of immune… CONTINUE READING
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