Evolution and Diversification of the Nuclear Receptor Superfamily a

  title={Evolution and Diversification of the Nuclear Receptor Superfamily a},
  author={Hector Escriv{\'a} and M C Langlois and Ricardo L. de Mendonça and R J Pierce and Vincent Laudet},
  journal={Annals of the New York Academy of Sciences},
Nuclear receptors play an important part in the regulation of cell growth and differentiation by providing a direct link between signaling molecules and the transcriptional response.1 These receptors are grouped into a large superfamily which includes receptors for steroid hormones, vitamin D, ecdysone, retinoic acids (alltrans or 9-cis isoforms), or thyroid hormones. It was recently discovered that fatty acids, farnesol, or prostaglandin J2 metabolites may act through binding to nuclear… Expand
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A complex evolutionary history for nuclear receptor genes in which gene duplication events and swapping between domains of different origins took place is suggested. Expand
The origin of nuclear receptor proteins: a single precursor distinct from other transcription factors.
Nuclear receptor proteins regulate transcription under the influence of hormones or other small ligands, and two evolutionary histories have bean proposed, which assume independent origins for the different domains. Expand
Phylogeny of the steroid receptor superfamily.
Both PAUP and N-J evolutionary trees showed that the receptors within the subgroups of a major sublineage tend to recognize hormones of very similar structure, which suggests that the relative phylogenetic position of orphans to well-characterized receptors might be exploited to predict the type of ligand they would recognize. Expand
Gene duplications and the origins of vertebrate development.
From amphioxus and vertebrate homeobox gene expression patterns, it is suggested that there are multiple routes by which new genes arising from gene duplication acquire new functions and permit the evolution of developmental innovations. Expand
Transcription factors 3: nuclear receptors.