Evolution: Hox genes and the cellared wine principle

Abstract

Two Drosophila Hox genes involved in segmentation, fushi tarazu and bicoid, appear to have acquired these roles by functional divergence from classical homeotic genes. Recent results indicate how genes with critical functions in development can evolve completely different functions among species. 
DOI: 10.1016/S0960-9822(00)00531-5

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