Evolution: Flu fitness model may inform vaccine selection

  • Linda Koch
  • Published 2014 in Nature Reviews Genetics

Abstract

A new fitness model has been developed that predicts evolution of the seasonal human influenza A/H3N2 virus from genomic data. The model is based on the fitness effects of mutations in antibody-binding epitope and in non-epitope regions of haemagglutinin, which is a surface protein of the virus. Beneficial mutations in epitopes and harmful (that is… (More)
DOI: 10.1038/nrg3711

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