Evolution: Conservation of a sex-determining gene

@article{Smith1999EvolutionCO,
  title={Evolution: Conservation of a sex-determining gene},
  author={Craig Allen Smith and Peter J. McClive and Patrick S Western and Kirsty J. Reed and Andrew H. Sinclair},
  journal={Nature},
  year={1999},
  volume={402},
  pages={601-602}
}
Vertebrates exhibit a surprising array of sex-determining mechanisms, including X- and Y-chromosome heterogametes in male mammals, Z- and W-chromosome hetero-gametes in female birds, and a temperature-dependent mechanism in many reptiles. The Y-chromosome-linked SRY gene initiates male development in mammals, but other vertebrates lack SRY and the genes controlling sex determination are largely unknown. Here we show that a gene implicated in human testis differentiation, DMRT1, has a gonad… Expand
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