Evolution: Conservation of a sex-determining gene

  title={Evolution: Conservation of a sex-determining gene},
  author={Craig Allen Smith and Peter J. McClive and Patrick S Western and Kirsty J. Reed and Andrew H. Sinclair},
Vertebrates exhibit a surprising array of sex-determining mechanisms, including X- and Y-chromosome heterogametes in male mammals, Z- and W-chromosome hetero-gametes in female birds, and a temperature-dependent mechanism in many reptiles. The Y-chromosome-linked SRY gene initiates male development in mammals, but other vertebrates lack SRY and the genes controlling sex determination are largely unknown. Here we show that a gene implicated in human testis differentiation, DMRT1, has a gonad… Expand
Monotreme sex chromosomes--implications for the evolution of amniote sex chromosomes.
The recent completion of the platypus genome sequence has completely changed the authors' understanding of when the therian mammal X and Y chromosomes first arose and has also revealed the unexpected insight that sex determination of the amniote ancestor might have been controlled by a bird-like ZW system. Expand
Sex chromosomes and sex-determining genes: insights from marsupials and monotremes.
  • A. Pask, J. Graves
  • Biology, Medicine
  • Cellular and molecular life sciences : CMLS
  • 1999
Comparative studies of the genes involved in sex determination in the three extant classes of mammals, and other vertebrates, has allowed us to identify genes that are highly conserved in vertebrateExpand
Genes and Mechanisms in Vertebrate Sex Determination
Endocrine and environmental aspects of sex differentiation in gonochoristic fish and sex chromosomes, sex-linked genes, and sex determination in the vertebrate class Amphibia are studied. Expand
Vertebrate sex determination: many means to an end.
It is shown that the interplay between genes in the regulatory network leading to gonad development differs between vertebrates, despite this, the development of a testis or ovary from a bipotential gonad is remarkably similar across vertebrates. Expand
Sex from W to Z: evolution of vertebrate sex chromosomes and sex determining genes.
It is suggested that sex determining genes can be made redundant, and replaced by control at another step of a conserved sex determining pathway, and how choice of a gene as a sex switch has led to the evolution of new sex chromosome systems. Expand
Evolution of the avian sex chromosomes and their role in sex determination.
  • Ellegren
  • Biology, Medicine
  • Trends in ecology & evolution
  • 2000
Despite the potentially common features of sex determination in mammals and birds, comparative mapping shows that the avian sex chromosomes have a different autosomal origin than the mammalian X and Y chromosomes. Expand
Sex determination: insights from the chicken.
  • C. Smith, A. Sinclair
  • Biology, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2004
The Z-linked gene, DMRT1, supports the Z-dosage model of avian sex determination, and two novel W-linked genes, ASW and FET1, represent candidate female determinants. Expand
Sex-specific expression of an evolutionarily conserved male regulatory gene, DMRT1, in birds
It is proposed that two gene dosages are required for testis formation in ZZ males, whereas expression from a single Z chromosome in ZW females leads to female sexual differentiation. Expand
Sex chromosome evolution in non-mammalian vertebrates.
  • M. Schartl
  • Biology, Medicine
  • Current opinion in genetics & development
  • 2004
Birds, reptiles, amphibia and fish have an enormous variety of chromosomal sex determination mechanisms that apparently do not follow any phylogenetic or taxonomic scheme. A similar picture is nowExpand
DMRT1/Dmrt1, the sex determining or sex differentiating gene in Vertebrata.
This work has given proof of evolutionarily conserved function in genes which share a novel DNA binding DM domain, primarily identified in two invertebrate sex regulatory genes: doublesex of Drosophila melanogaster and mab-3 of Caenorhabditis elegans. Expand


Evidence for evolutionary conservation of sex-determining genes
The male sexual regulatory gene mab-3 from the nematode Caenorhabditis elegans is isolated and found that it is related to the Drosophila melanogasterSexual regulatory gene doublesex (dsx), which encodes proteins with a DNA-binding motif that is named the ‘DM domain’. Expand
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene, termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-d determining gene, TDF. Expand
A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators.
It is shown by fluorescence in situ hybridization analysis that both genes are deleted in the smallest reported sex-reversing 9p deletion, suggesting that gonadal dysgenesis in 9p-deleted individuals might be due to combined hemizygosity of D MRT1 and DMRT2. Expand
Male development of chromosomally female mice transgenic for Sry
It is shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos. Expand
A gene involved in XY sex reversal is located on chromosome 9, distal to marker D9S1779.
Conventional and molecular cytogenetic analyses of metaphase chromosomes from each patient suggest that the smallest region of overlap (SRO) of deletions involves a very small region of distal band 9p24, significantly narrow the putative sex-determining gene to the very terminal region of the short arm of chromosome 9. Expand
Molecular analysis of 9p deletions associated with XY sex reversal: refining the localization of a sex-determining gene to the tip of the chromosome.
This work was supported by Welcome grant 035201/Z/92, EU grant Biomed2-CT960790, Telethon research fellowship, and an EMBO long-term fellowship. Expand
Evolution of sex determining mechanisms
Books, as a source that may involve the facts, opinion, literature, religion, and many others are the great friends to join with. Expand