Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs.

@article{Ruby2007EvolutionBE,
  title={Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs.},
  author={J. G. Ruby and Alexander Stark and Wendy K. Johnston and Manolis Kellis and David P. Bartel and Eric C. Lai},
  journal={Genome research},
  year={2007},
  volume={17 12},
  pages={1850-64}
}
MicroRNA (miRNA) genes give rise to small regulatory RNAs in a wide variety of organisms. We used computational methods to predict miRNAs conserved among Drosophila species and large-scale sequencing of small RNAs from Drosophila melanogaster to experimentally confirm and complement these predictions. In addition to validating 20 of our top 45 predictions for novel miRNA loci, the large-scale sequencing identified many miRNAs that had not been predicted. In total, 59 novel genes were identified… CONTINUE READING
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