Evolution, atmospheric oxygen, and complex disease.

  title={Evolution, atmospheric oxygen, and complex disease.},
  author={Lauren G Koch and Steven Loyal Britton},
  journal={Physiological genomics},
  volume={30 3},
If evolution is an accurate statement of our biology, then disease must be tightly associated with its patterns. We considered selection for more optimal capacity for energy transfer as the most general pattern of evolution. From this, we propose that the etiology of complex disease is linked tightly to the evolutionary transition to cellular complexity that was afforded by the steep thermodynamic gradient of an oxygen atmosphere. In accord with this thesis, clinical studies reveal a strong… CONTINUE READING

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