Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

@article{Sabatine2017EvolocumabAC,
  title={Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease},
  author={Marc S. Sabatine and Robert P. Giugliano and Anthony C. Keech and Narimon Honarpour and Stephen D. Wiviott and Sabina A. Murphy and Julia Kuder and Huei Wang and Thomas Liu and Scott M. Wasserman and Peter S Sever and Terje Rolf Pedersen},
  journal={The New England Journal of Medicine},
  year={2017},
  volume={376},
  pages={1713–1722}
}
BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin–kexin type 9 (PCSK9) and lowers low‐density lipoprotein (LDL) cholesterol levels by approximately 60. [] Key Method Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections.

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