Evoked expression of the glutamate transporter GLT-1c in retinal ganglion cells in human glaucoma and in a rat model.

@article{Sullivan2006EvokedEO,
  title={Evoked expression of the glutamate transporter GLT-1c in retinal ganglion cells in human glaucoma and in a rat model.},
  author={Robert K P Sullivan and Elizabeth Woldemussie and Lauren T Macnab and Guadalupe Ruiz and David V. Pow},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 9},
  pages={3853-9}
}
PURPOSE Glaucoma is a common disease of the eye, a key characteristic consequence of which is the death of retinal ganglion cells. The cause of this loss is unknown, though glutamate-mediated toxicity has been implicated. Glutamate transporters are key regulators of glutamate; therefore, the purpose of the study was to determine whether unusual excitation is associated with unusual expression of one or more transporters. METHODS The expression of a splice variant of the glutamate transporter… CONTINUE READING

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