Evo-Devo of the Mammary Gland

  title={Evo-Devo of the Mammary Gland},
  author={Olav T. Oftedal and Danielle Dhouailly},
  journal={Journal of Mammary Gland Biology and Neoplasia},
We propose a new scenario for mammary evolution based on comparative review of early mammary development among mammals. Mammary development proceeds through homologous phases across taxa, but evolutionary modifications in early development produce different final morphologies. In monotremes, the mammary placode spreads out to form a plate-like mammary bulb from which more than 100 primary sprouts descend into mesenchyme. At their distal ends, secondary sprouts develop, including pilosebaceous… 

Embryonic Mammary Gland Development

Parallels, such as invasiveness, exist between the development of embryonic mammary glands and breast tumours and many of same molecules are involved.

Embryonic mammary gland development.

Conserved and variable: Understanding mammary stem cells across species

Identification and comparison of MaSC across a large variety of species, particularly those with extreme lactational adaptations or low mammary cancer incidence, is expected to deepen the understanding of development and malignancy in the mammary gland.

Prenatal Mammary Gland Development in the Mouse: Research Models and Techniques for Its Study from Past to Present.

This review describes embryonic Mammary gland development in mouse only, and lists mouse models that have been examined for defects in embryonic mammary development, and illustrated how generic molecular biology and biochemistry techniques can be combined with older, developmental biology techniques, to address relevant research questions.

Evolution of mammary gland function: a study using monotreme models

EchAMP protein, a novel, monotremespecific gene, found to be abundantly expressed in echidna milk cells during lactation, indicates that EchAMP is capable of conferring protection to the underdeveloped, immunologically naïve young outside the sterile confines of the uterus.

Mammalian tumor-like organs. 1. The role of tumor-like normal organs and atypical tumor organs in the evolution of development (carcino-evo-devo)

  • A. P. Kozlov
  • Medicine, Biology
    Infectious agents and cancer
  • 2022
Tumor-like organs might originate from hereditary atypical tumor organs and represent the part of carcino-evo-devo relationships, i.e., coevolution of normal and neoplastic development.

ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation

It is demonstrated thatErbB3, like ErbB4, enhances lactogenic expansion and differentiation of the mammary gland during pregnancy, through activation of Akt and STAT5A, two targets crucial for lactation.

Retrotransposons spread potential cis-regulatory elements during mammary gland evolution

It is demonstrated that thousands of binding sites for estrogen receptor α (ERα) and three related pioneer factors that are essential regulators of mammary gland development arose from a spreading of the binding motifs by retrotransposons.

Prenatal Morphogenesis of Mammary Glands in Mouse and Rabbit

This review focuses on morphogenesis proper, as well as cellular processes and tissue interactions involved in the progression of the embryonic mammary gland through sequential morphogenic stages in both the mouse and rabbit embryo.



The Mammary Gland and Its Origin During Synapsid Evolution

  • O. Oftedal
  • Biology
    Journal of Mammary Gland Biology and Neoplasia
  • 2004
The mammary gland apparently derives from an ancestral apocrine-like gland that was associated with hair follicles, which is retained by monotreme mammary glands and is evident as vestigial mammary hair during early ontogenetic development of marsupials.

Organ specificity in mesenchymal induction demonstrated in the embryonic development of the mammary gland of the mouse.

Differential requirements for shh in mammary tissue and hair follicle morphogenesis.

It is demonstrated that neither Shh nor Ihh is required for mammary gland morphogenesis and functional differentiation, suggesting that the two members of the Hedgehog family may have redundant function in activating the Ptc1 signaling pathway during mammary glands development.

The Nipple: A Simple Intersection of Mammary Gland and Integument, but Focal Point of Organ Function

The physiology of lactation and the cell biology of nipples are summarized with specific focus on comparing these in the mouse, cow, and human, which represent the three different groups.

Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation.

This review describes how mouse embryonic mammogenesis depends on a continuous communication between the epithelial and mesenchymal compartment of the mammary rudiment and suggests that different molecular mechanisms may underlie the formation of such identical structures.

Molecular mechanisms guiding embryonic mammary gland development.

The distinct stages of embryonic mammary development are outlined and the molecular pathways involved in the regulation of morphogenesis at each stage are discussed, including the potential relevance of embryonic breast development to the pathophysiology of breast cancer.

Evo-Devo of amniote integuments and appendages.

In mammals, tilting the balance of the BMP pathway in K14 noggin transgenic mice alters the number, size and phenotypes of different ectodermal organs, making investigators rethink the distinction between morpho-regulation and pathological changes.

The evolution of milk secretion and its ancient origins.

  • O. Oftedal
  • Medicine, Biology
    Animal : an international journal of animal bioscience
  • 2012
Comparative analyses of the evolutionary origin of milk constituents support a scenario in which these secretions evolved into a nutrient-rich milk long before mammals arose, and some constituents may have origins that predate the split of the synapsids from sauropsids.

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

It is found that activation of the canonical WNT/β-catenin signaling pathway in the embryonic mouse mammary region coincides with initiation of mammary morphogenesis, and that WNT pathway activity subsequently localizes to mammary placodes and buds.