Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice

  title={Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice},
  author={D. Dhingra and V. Kumar},
  journal={Indian Journal of Pharmacology},
  pages={175 - 179}
  • D. Dhingra, V. Kumar
  • Published 2008
  • Medicine
  • Indian Journal of Pharmacology
  • Objectives: The present study was undertaken to investigate the effect of the ethanolic extract of Allium sativum L. (Family: Lilliaceae), commonly known as garlic, on depression in mice. Materials and Methods: Ethanolic extract of garlic (25, 50 and 100 mg/kg) was administered orally for 14 successive days to young Swiss albino mice of either sex and antidepressant-like activity was evaluated employing tail suspension test (TST) and forced swim test (FST). The efficacy of the extract was… CONTINUE READING
    29 Citations
    Antidepressant-like effect of extract from Polygala paniculata: Involvement of the monoaminergic systems
    • 11
    Involvement of monoaminergic systems in the antidepressant-like effect of Eugenia brasiliensis Lam. (Myrtaceae) in the tail suspension test in mice.
    • 29
    Antidepressant-like activity of Benincasa hispida fruits in mice: Possible involvement of monoaminergic and GABAergic systems
    • 13
    GABAergic and nitriergic influence in antianxiety-like Activity of Garlic in Mice
    • 3
    • PDF
    Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice
    • 11
    • Highly Influenced


    Antidepressant-like effect of icariin and its possible mechanism in mice
    • 99
    Antidepressant activity of aqueous extracts of Curcuma longa in mice.
    • 231
    The tail suspension test: A new method for screening antidepressants in mice
    • 2,609
    The neuropharmacology of serotonin and noradrenaline in depression
    • D. Nutt
    • Psychology, Medicine
    • International clinical psychopharmacology
    • 2002
    • 206
    [Antidepressant amides from Piper laetispicum C. DC].
    • 9
    Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock.
    • 206
    Evidence for a biochemical lesion in depression.
    • B. Leonard
    • Medicine
    • The Journal of clinical psychiatry
    • 2000
    • 42
    Effect of garlic and garlic preparations on physiological and psychological stress in mice
    • 21