Evidences for protein kinase C. Activation in T lymphocytes by stimulation of either the CD2 or CD3 antigens.

@article{Friedrich1989EvidencesFP,
  title={Evidences for protein kinase C. Activation in T lymphocytes by stimulation of either the CD2 or CD3 antigens.},
  author={Brian Friedrich and Doreen A Cantrell and Martin Gullberg},
  journal={European journal of immunology},
  year={1989},
  volume={19 1},
  pages={17-23}
}
Phosphorylation of protein kinase C (PKC) substrates in T lymphocytes was analyzed after stimulation with specific pairs of anti-CD2 monoclonal antibodies (mAb) or an anti-CD3 mAb. The results show that the appropriate stimulation of both CD2 or CD3 antigens results in phosphorylation of a 80-kDa putative PKC substrate and that this phosphorylation event is sensitive to a PKC inhibitor, sphinganine. CD2- and CD3-dependent phosphorylation was found to be strongly dependent on an extensive cross… CONTINUE READING