Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction.

@article{Pudney2009EvidenceTS,
  title={Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction.},
  author={Christopher R. Pudney and Sam Hay and Colin Levy and Jiayun Pang and Michael J. Sutcliffe and David Leys and Nigel S. Scrutton},
  journal={Journal of the American Chemical Society},
  year={2009},
  volume={131 47},
  pages={17072-3}
}
In recent years there has been a shift away from transition state theory models for H-transfer reactions. Models that incorporate tunneling as the mechanism of H-transfer are now recognized as a better description of such reactions. Central to many models of H-tunneling is the notion that specific vibrational modes of the protein and/or substrate can increase the probability of a H-tunneling reaction, modes that are termed promoting vibrations. Thus far there has been limited evidence that… CONTINUE READING