Evidence that xeroderma pigmentosum cells do not perform the first step in the repair of ultraviolet damage to their DNA.

Abstract

Xeroderma pigmentosum (XP) is a recessively transmitted disorder of man characterized by increased sensitivity to ultraviolet light. Homozygous, affected individuals, upon exposure to sunlight, sustain severe damage to the skin; this damage is characteristically followed by multiple basal and squamous cell carcinomas and not uncommonly by other malignant… (More)

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