Evidence that toxic injury is not always associated with induction of chemical carcinogenesis.

  title={Evidence that toxic injury is not always associated with induction of chemical carcinogenesis.},
  author={Raymond W. Tennant and Michael R. Elwell and J. W. Spalding and Richard A. Griesemer},
  journal={Molecular carcinogenesis},
  volume={4 6},
Long-term rodent bioassays with chemicals administered at maximum tolerated doses identify noncarcinogens as well as carcinogens. Thirty-one chemicals recently evaluated for carcinogenic potential by the National Toxicology Program provide unique data on the relationships between mutagenicity, toxicity, and carcinogenicity. Twenty-two substances were classified as carcinogens, and nine showed no evidence of carcinogenicity. Although cellular proliferation does play an intrinsic role in… CONTINUE READING


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