Evidence that the soluble factors secreted by activated immune cells suppress replication of human neurotropic JC virus DNA in glial cells.

@article{Chang1996EvidenceTT,
  title={Evidence that the soluble factors secreted by activated immune cells suppress replication of human neurotropic JC virus DNA in glial cells.},
  author={Celia Chang and Jessica Otte and Don Kerr and Merja V{\"a}lkkil{\"a} and Carrol Calkins and Kamel Khalili},
  journal={Virology},
  year={1996},
  volume={221 1},
  pages={226-31}
}
Coordination of the immune response to viral infection and disease in the brain is believed to involve bidirectional interaction between the immune system and the central nervous system (CNS). Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the CNS that generally affects patients exhibiting an immunocompromised condition due to various illnesses. The human polyomavirus, JCV, which infects greater than 70% of the adult population is the etiological agent of this… CONTINUE READING