Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain.

@article{Ferris1986EvidenceTT,
  title={Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain.},
  author={R. Ferris and F. Tang and K. J. Chang and A. Russell},
  journal={Life sciences},
  year={1986},
  volume={38 25},
  pages={
          2329-37
        }
}
  • R. Ferris, F. Tang, +1 author A. Russell
  • Published 1986
  • Chemistry, Medicine
  • Life sciences
  • Rimcazole (BW 234U) is a potential antipsychotic agent which in open-clinical trials appears to be effective in acute schizophrenic patients. In the present study, rimcazole was found to block the specific binding of [3H]-(+)-SKF 10,047 to sigma sites in rat and guinea pig brain (IC50 = 5.0 X 10(-7) M). The compound was 100 times weaker as a blocker of phencyclidine sites (IC50 = 4.3 X 10(-5) M). At 1 X 10(-5) M, rimcazole had only weak effects on mu, delta, kappa and epsilon opioid receptors… CONTINUE READING
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