Evidence that the physiological pulse frequency of glucagon secretion optimizes glucose production by perifused rat hepatocytes.

@article{Weigle1986EvidenceTT,
  title={Evidence that the physiological pulse frequency of glucagon secretion optimizes glucose production by perifused rat hepatocytes.},
  author={David S. Weigle and Charles J Goodner},
  journal={Endocrinology},
  year={1986},
  volume={118 4},
  pages={1606-13}
}
We have reported that glucagon administered to perifused rat hepatocytes as a series of pulses at 15-min intervals is a more effective stimulus for hepatocyte glucose production (HGP) than is continuous glucagon infusion. To test whether the efficiency of HGP depends upon the frequency of pulsatile glucagon delivery, we administered glucagon to perifused rat hepatocytes as a series of pulses of fixed amplitude [922 +/- 30 (+/- SE) pg/ml] at eight separate pulse intervals ranging from 3-45 min… CONTINUE READING

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