Evidence that the neurotrophic actions of alpha-MSH may derive from its ability to mimick the actions of a peptide formed in degenerating nerve stumps.

Abstract

The ability of alpha-MSH to facilitate the recovery of sensorimotor nerve function following crush lesion is restricted to a critical period following such a lesion. This period coincided with the initiation of sprouting and the disappearance of the 150 kD neurofilament protein from the degenerating distal stump of the nerve. Degenerating nerve contains a factor that is active in a bioassay system for MSH. This factor could not be detected in control nerves. The hypothesis is forwarded that a neurotrophic factor known to be present in degenerating nerve stumps is an alpha-MSH-like peptide formed by the breakdown of the 150 kD neurofilament protein.

Cite this paper

@article{Edwards1984EvidenceTT, title={Evidence that the neurotrophic actions of alpha-MSH may derive from its ability to mimick the actions of a peptide formed in degenerating nerve stumps.}, author={Paul M Edwards and Catharina E.E.M. Van der Zee and Joost Verhaagen and Peter C. Schotman and Frans G. I. Jennekens and Willem Hendrik Gispen}, journal={Journal of the neurological sciences}, year={1984}, volume={64 3}, pages={333-40} }